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140 J KARDIOL 2008; 15 (5–6)
ÖKG-Jahrestagung – Abstracts
of hyperlipedaemia among ACS patients was higher for high alti-
tude patients (56.4 % and 39.7 %; CI = 1.02–3.75; p = 0.040).
Betablocker use was higher for low altitude patients (49.2 % vs
31.9 %; CI = 0.251–0.934; p = 0.02). Streptokinase, diuretics,
ACE-I and statins were prescribed more frequently for high altitude
patients, while heparin was prescribed more frequently to low alti-
tude patients. The hospital and one year mortality rates were slightly
higher among high altitude patients.
Conclusion Acute coronary syndrome occurs at a younger age at
high altitude residence. During hospitalization, after 6 months and
1 year follows up, HR, SBP, DBP, incidence of HF and reduced
LVEF were higher for high altitude patients. High altitude ACS pa-
tients also have more prevalent cardiovascular risk factors. They
also demonstrated more severe complications and more adverse
clinical outcome. These findings suggest that high altitude itself
should be considered as an independent risk factor for ACS.
Prognostic Significance of Body Mass Index and
Body Fatness in Women Undergoing Coronary
Angiography 107
M. Ammer, T. Weber, M. Rammer, S. Lengauer, E. Lassnig, M. Porodko, B. Eber
Department of Internal Medicine II, Klinikum Wels
Purpose We sought to evaluate the prognostic significance of
simple measures of obesity (body mass index – BMI and body fat-
ness – BF) in elderly women with known coronary anatomy. Former
studies showed contradictory results concerning the relation be-
tween obesity, and total and cardiovascular mortality in coronary
artery disease (CAD) patients.
Methods In 393 women undergoing coronary angiography for
suspected CAD, BMI was calculated using standard formula, BF
measured using bioelectrical impedance analysis.
Results Mean age was 67.2 ± 10.1 years, 20.4 % had diabetes,
75.1 % arterial hypertension, 56 % CAD and 22.6 % impaired
systolic function. Mean BMI was 28.1 ± 4.7 kg/m
2
, mean BF 39.0 ±
6.2 %. During a mean follow-up of 44.4 months, 46 patients died
(24 from cardiovascular causes). We observed a tight correlation
between BMI and BF (r = 86; p < 0.0001). BF by tertile (T) was:
T1 < 37 %, T2 37–41.9 % and T3 42 %. The unadjusted inci-
dence of all-cause and cardiovascular mortality demonstrated an U-
shaped relationship to BF, with the lowest risk for all-cause mortal-
ity (unadjusted hazard ratios: T1 3.9 [CI 1.6–6.7], T2 reference, T3
2.4 [CI 0.96–5.1]) and cardiovascular mortality (unadjusted hazard
ratios: T1 13.1 [CI 1.9–14.6], T2 reference, T3 7.9 [CI 1.3–15.2]) in
T2. In multivariable analysis, including age, extent of CAD, left
ventricular function, diabetes and presence of malignancy as co-
variates, results were substantially unchanged. In contrast, we
found no significant relationship between BMI and all-cause or car-
diovascular mortality.
Conclusions In our cohort, BF analysis was a better prognostic
marker than BMI. Our results come up to controversial findings that
a mildly elevated BF is linked to better survival and fewer cardio-
vascular events in patients with CAD.
Reference Values of NT-proBNP are Elevated in
Healthy Pregnancies 074
M. B. Franz*
1
, M. Andreas*
2
, B. Schiessl
1
, H. Zeisler
3
, A. Neubauer
1
, S. Kastl
2
,
G. Hess
4
, F. Rhomberg
2
, D. Zdunek
4
, G. Maurer
2
, D. Schlembach
5
, T. Szekeres
6
,
M. Gottsauner-Wolf
2
1
1
st
Department of Obstetrics and Gynecology, University of Munich, Germany;
2
Department of Cardiology, Medical University of Vienna, Austria;
3
Department of
Obstetrics and Gynecology, Medical University of Vienna, Austria;
4
Roche Diag-
nostics, Mannheim;
5
Department of Obstetrics and Gynecology, Medical Univer-
sity of Graz, Austria;
6
Department of Laboratory Medicine, Medical University of
Vienna, Austria; *both authors contributed equally to this study
Objective Serum concentration of Amino-terminal pro-B-type
Natriuretic Peptide (NT-proBNP) may be used to monitor cardiac
function during pregnancy. We investigated NT-proBNP in nor-
motensive healthy pregnancies to determine normal reference val-
ues.
Methods Serum NT-proBNP were measured in 110 normoten-
sive, healthy pregnant women between 18 and 45 years every 5
weeks beginning from 12
th
gestational week (GW) in a longitudinal
study and compared to a non pregnant control group of 521 women
between 18 and 45 years.
Results Serum NT-proBNP (± SEM) was significantly higher
in pregnant women compared with non pregnant women (71.61
[± 2.79] pg/ml vs 48.37 [± 1.44] pg/ml [p < 0.001]). NT-proBNP
increased during pregnancy to 95.76 (± 7.42) pg/ml in the 11+6 to
13+6 GW. However, NT-proBNP levels in the 33+0–37+6 GW
were comparable to not pregnant levels, but increased again to
70.46 (± 7.2) pg/ml close to term.
Conclusion NT-proBNP is significantly higher in healthy preg-
nancies than in non-pregnant women. An upper cut-off value of
220 pg/ml may be used for normal NT-proBNP levels during 11+6
to 22+6 GW.
Erste Erfahrungen mit einem MR-tauglichen Herz-
schrittmacher: Medtronic ENRHYTHM MRI 048
M. Anelli-Monti, G. Prenner, K. H. Tscheliessnigg
Klinische Abteilung für Herzchirurgie, Medizinische Universität Graz
Das Enrythm MRI-System besteht aus dem MR-tauglichen Schritt-
macher Medtronic ENRHYTHM MRI mit speziellen Programmier-
möglichkeiten und MR-tauglichen Sonden Capsurefix MRI 5086.
An der Universitätsklinik für Chirurgie Graz wurden im Zeitraum
8/2007–2/2008 10 Patienten mit diesem System versorgt (5 Män-
ner, 5 Frauen, mittleres Alter 46 Jahre). Indikation zur Schrittma-
chertherapie war SSS bei 4 und AV-Block bei 6 Patienten. Bislang
wurden 3 Patienten im MR mittels standardisiertem MR des Schä-
dels und der WS untersucht. Während der MR-Untersuchung wurde
der Schrittmacher in AOO bei 2 Patienten und ODO bei einem Pati-
enten programmiert.
Ergebnisse Während der MR-Untersuchung kam es zu keiner
Störung der Schrittmacherfunktion, die Reizschwellen waren un-
verändert. Lediglich das EKG zeigte auffällige Veränderungen, so-
dass bei einer MR-Untersuchung unbedingt eine simultane Puls-
oxymetrie notwendig ist.
Prevention, Physical Exercise 013
A. Bader, M. Hochleitner
Women’s Health Centre, Medical University of Innsbruck
The Women’s Health Centre for Tyrol focuses on cardiac preven-
tion. Numerous information events and diagnosis campaigns are
offered, where heart risk profiles are drawn up. In self-assessment
by our patients, on average 90 % reply that they get ample physical
exercise, even though we on average do not believe it.
Our out-patient clinic for Turkish women shows that physical exer-
cise entails special problems. This fact is known in this group and
from the literature, and the patients also admit it. At 2 prevention
campaigns in 2000 and 2001 we surveyed 1,536 women. Physical
exercise at least three times a week for thirty minutes received a
positive reply from only 1/4 (403; 26.2 %) of the women, while 3/4
(1,126; 73.3 %) denied it and 7 (0.5 %) gave no answer. Since com-
pliance is particularly questionable in this area, we decided to make
an initiative through the Turkish women’s out-patient clinic. First
was a “Walk” campaign. Once a week a one-hour accompanied
walk through town was made, starting from the hospital. The
women were examined before and after the program for heart risk
factors, and incentives were offered for them get more exercise in
the hope that networks for group walking would develop. There-
after, an “Exercise Group” was started with healthy Turkish women
who promised to exercise at the hospital for one hour once a week
and to also do exercises at home.
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